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Description
Celebrex capsules 200mg contain celecoxib, a nonsteroidal anti-inflammatory drug (NSAID) classified as a selective COX-2 inhibitor. It is primarily used to treat pain, inflammation, and swelling caused by conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain including menstrual pain, and juvenile rheumatoid arthritis in certain cases.
The mechanism of action of celecoxib involves selectively inhibiting the cyclooxygenase-2 (COX-2) enzyme, which reduces the production of prostaglandins. Prostaglandins are chemicals in the body that cause inflammation, pain, and fever. By targeting COX-2 selectively, celecoxib aims to reduce inflammation and pain with a lower risk of gastrointestinal side effects compared to non-selective NSAIDs.
Celebrex is available in capsule form for oral administration.
Typical dosage for adults with osteoarthritis or rheumatoid arthritis is usually 200 mg once daily or 100 mg twice daily. For acute pain or menstrual pain, doses may be 400 mg initially, followed by 200 mg if needed on the first day. Dosages should be adjusted based on the specific medical condition and patient response, and always under healthcare provider guidance.
Common side effects include stomach pain, indigestion, diarrhea, headache, dizziness, and respiratory infections. Serious side effects can involve cardiovascular risks, gastrointestinal bleeding, kidney problems, or allergic reactions.
Celebrex is contraindicated in patients with known hypersensitivity to celecoxib or other NSAIDs, history of asthma or allergic reactions related to NSAIDs, active gastrointestinal bleeding, severe heart failure, or those in the third trimester of pregnancy.
Drug interactions can occur with anticoagulants, antihypertensives, lithium, and some other medications, so medical supervision is important during treatment.
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