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Description
Celecoxib capsules 200mg (UK generics) contain celecoxib, a nonsteroidal anti-inflammatory drug (NSAID) belonging to the class of selective COX-2 inhibitors. It is primarily used to relieve pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute pain including menstrual pain.
The mechanism of action involves selective inhibition of the cyclooxygenase-2 (COX-2) enzyme, which results in the reduction of prostaglandin synthesis, substances that mediate inflammation, pain, and fever. By targeting COX-2 specifically, celecoxib aims to reduce inflammation and pain while minimizing gastrointestinal side effects common with non-selective NSAIDs.
Celecoxib is available in capsule form for oral administration.
Typical dosage varies depending on the condition being treated but commonly includes a dose of 200 mg once daily or 100 mg twice daily for osteoarthritis, and up to 200 mg twice daily for conditions like rheumatoid arthritis. Dosage should always be as prescribed by a healthcare professional.
Common side effects may include abdominal pain, diarrhea, indigestion, headache, dizziness, and upper respiratory tract infections. Serious side effects can include cardiovascular events, gastrointestinal bleeding, or allergic reactions, especially in patients with existing heart or gastrointestinal conditions.
Celecoxib is contraindicated in patients with known hypersensitivity to celecoxib or other NSAIDs, history of aspirin or NSAID-induced asthma, active gastrointestinal bleeding, and severe heart failure.
It may interact with other medications such as anticoagulants, antihypertensives, and certain antidepressants, necessitating medical supervision during use.
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