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Description
Glucovance 500/5mg is a prescription medication used to manage type 2 diabetes mellitus in adults. It combines two active ingredients: metformin hydrochloride (500 mg) and glibenclamide (5 mg).
**Primary Medical Uses:**
– Improves glycemic control in adults with type 2 diabetes.
**Drug Class or Type:**
– Antidiabetic combination.
**General Mechanism of Action:**
– Metformin reduces hepatic glucose production and enhances insulin sensitivity.
– Glibenclamide stimulates insulin secretion from pancreatic beta cells.
**Common Forms:**
– Oral tablet.
**Dosage Instructions:**
– Typically, one tablet is taken twice daily with meals.
– Dosage should be individualized based on effectiveness and tolerance, not exceeding 2000 mg of metformin and 20 mg of glibenclamide per day.
– Gradual dose escalation is recommended to minimize gastrointestinal side effects and reduce the risk of hypoglycemia.
**Side Effects, Contraindications, or Interactions:**
– Common side effects may include diarrhea, nausea, and abdominal discomfort.
– Serious side effects can include lactic acidosis, hypoglycemia, and allergic reactions.
– Contraindicated in patients with known hypersensitivity to metformin or glibenclamide, type 1 diabetes, diabetic ketoacidosis, severe renal or hepatic impairment, and certain other conditions.
– Alcohol consumption should be limited due to the risk of hypoglycemia and lactic acidosis.
– Use with caution in patients with renal or hepatic dysfunction.
Glucovance 500/5mg is intended to be used as part of a comprehensive diabetes management plan, including diet and exercise. Regular monitoring of blood glucose levels is essential to ensure optimal therapeutic outcomes.
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