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Description
Isosorbide dinitrate is a medication used to prevent and treat chest pain (angina) associated with coronary artery disease.
**Primary Uses:**
– Prevention and treatment of angina pectoris.
**Drug Class:**
– Antianginal agent.
**General Mechanism of Action:**
– Isosorbide dinitrate dilates blood vessels, reducing the heart’s workload and improving blood flow to the heart muscle.
**Common Forms:**
– Oral tablets, typically in 5 mg, 10 mg, 20 mg, 30 mg, and 40 mg strengths.
**Dosage Instructions:**
– The usual starting dose is 5 to 20 mg taken two or three times daily.
– A daily nitrate-free interval of at least 14 hours is advisable to minimize tolerance.
– Dosage may be adjusted based on individual response and tolerability.
**Side Effects, Contraindications, or Interactions:**
– Common side effects include headaches, dizziness, lightheadedness, and low blood pressure.
– Contraindicated in patients with severe anemia, closed-angle glaucoma, or hypersensitivity to nitrates.
– Use with caution in patients with hypotension, hypovolemia, or conditions that may predispose to hypotension.
– May interact with other vasodilators, alcohol, and medications for erectile dysfunction, leading to enhanced hypotensive effects.
– Avoid concurrent use with phosphodiesterase inhibitors (e.g., sildenafil) due to the risk of severe hypotension.
Always consult a healthcare professional before starting or adjusting the dosage of isosorbide dinitrate.
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