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Description
Kombiglyze XR 5/1000mg is a combination medication used to manage type 2 diabetes mellitus.
Primary Medical Uses:
– It helps to control high blood sugar levels in adult patients with type 2 diabetes.
Drug Class or Type:
– It is a fixed-dose oral antidiabetic combination.
– Contains two active ingredients: Saxagliptin (a DPP-4 inhibitor) and Metformin (a biguanide).
General Mechanism of Action:
– Saxagliptin works by inhibiting the enzyme DPP-4, which increases the levels of incretin hormones. These hormones help the body produce more insulin when blood sugar is high and reduce glucose production by the liver.
– Metformin decreases glucose production in the liver and improves insulin sensitivity to enhance glucose uptake by muscles and tissues.
Common Forms:
– Extended-release oral tablets taken once daily.
Dosage Instructions:
– The usual dose contains 5 mg of Saxagliptin and 1000 mg of Metformin.
– Taken orally, once daily with meals to reduce gastrointestinal side effects.
– Dosage may be adjusted by the healthcare provider based on the patient’s response and tolerance.
Side Effects, Contraindications, or Interactions:
– Common side effects include gastrointestinal symptoms such as nausea, diarrhea, and abdominal discomfort.
– Other possible side effects are headache, upper respiratory tract infections, and hypoglycemia, especially when combined with other antidiabetic drugs.
– Contraindicated in patients with severe kidney or liver disease, metabolic acidosis, or hypersensitivity to either component.
– Should be used cautiously with medications that affect kidney function or increase lactic acidosis risk.
Regular monitoring of blood sugar and kidney function is advised during treatment.
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