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Description
Malarone Paediatric Tablets are a combination medication used for the prevention and treatment of malaria in children.
**Active Ingredients:**
– Atovaquone 62.5 mg
– Proguanil hydrochloride 25 mg
**Primary Medical Uses:**
– Prevention of malaria
– Treatment of malaria
**Drug Class:**
– Antimalarial
**Mechanism of Action:**
– Atovaquone disrupts the mitochondrial electron transport in Plasmodium falciparum, inhibiting ATP synthesis.
– Proguanil hydrochloride inhibits dihydrofolate reductase, leading to decreased folate synthesis in the parasite.
**Common Forms:**
– Tablets
**Dosage Instructions:**
– **For Malaria Prevention:**
– Children weighing 11–20 kg: 1 tablet once daily
– Children weighing 21–30 kg: 2 tablets once daily
– Children weighing 31–40 kg: 3 tablets once daily
– Start 1–2 days before entering a malarious area, continue daily during the stay, and for 7 days after leaving.
– **For Malaria Treatment:**
– Children weighing 5–8 kg: 2 tablets once daily for 3 days
– Children weighing 9–10 kg: 3 tablets once daily for 3 days
– Children weighing 11–20 kg: 1 adult tablet once daily for 3 days
– Children weighing 21–30 kg: 2 adult tablets once daily for 3 days
– Children weighing 31–40 kg: 3 adult tablets once daily for 3 days
Malarone Paediatric Tablets should be taken with food or a milky drink. For children who find it difficult to swallow tablets, they may be crushed and mixed with food or a milky drink just before taking. It is important to complete the full course of treatment to ensure effectiveness.
Before starting Malarone Paediatric Tablets, consult a healthcare professional to ensure appropriate dosing and to discuss any potential interactions or contraindications.
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