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Description
Caffeine Citrate 10mg/ml Solution for Injection is a medication primarily used to treat apnea of prematurity in neonates. Each milliliter of the solution contains 10 mg of caffeine citrate, equivalent to 5 mg of caffeine base. ([medicines.org.uk](https://www.medicines.org.uk/emc/product/5146/smpc?utm_source=openai))
The recommended dosing regimen involves an initial loading dose of 20 mg/kg of caffeine citrate (10 mg/kg of caffeine base), administered intravenously over 30 minutes or orally, followed by a maintenance dose of 5–10 mg/kg of caffeine citrate (2.5–5.0 mg/kg of caffeine base) every 24 hours, starting 24 hours after the loading dose. ([medicines.org.uk](https://www.medicines.org.uk/emc/product/5146/smpc?utm_source=openai))
Caffeine citrate is contraindicated in patients with known hypersensitivity to any of its components. Caution is advised in neonates with renal or hepatic impairment, as these conditions may affect caffeine metabolism and clearance. ([medicines.org.uk](https://www.medicines.org.uk/emc/product/5146/smpc?utm_source=openai))
The solution should be administered intravenously; intramuscular injection is not recommended due to potential pain and tissue irritation. Additionally, the solution should be filtered prior to use to remove any glass particles that may have been introduced during opening. ([medicines.org.uk](https://www.medicines.org.uk/emc/product/5146/smpc?utm_source=openai))
Caffeine citrate is intended for use under the supervision of healthcare professionals experienced in neonatal intensive care, with appropriate monitoring of the neonate’s response to treatment. ([medicines.org.uk](https://www.medicines.org.uk/emc/product/5146/smpc?utm_source=openai))
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