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Description
Ledipasvir and Sofosbuvir tablets (90 mg + 400 mg) are a combination antiviral medication used to treat chronic hepatitis C virus (HCV) infection.
Primary Medical Uses:
– Treatment of chronic hepatitis C infection, including genotype 1, 4, 5, and 6.
– Used to achieve sustained virologic response (SVR), effectively curing the infection in many cases.
Drug Class or Type:
– Direct-acting antiviral agents (DAAs).
General Mechanism of Action:
– Ledipasvir is an NS5A inhibitor that blocks a viral protein essential for hepatitis C virus replication.
– Sofosbuvir is an NS5B polymerase inhibitor that interferes with viral RNA replication.
– Together, they prevent the virus from multiplying, allowing the immune system to clear the infection.
Common Forms:
– Oral tablets, typically taken once daily.
Dosage Instructions:
– Usually prescribed as one tablet once daily with or without food.
– Treatment duration commonly ranges from 12 to 24 weeks depending on the patient’s HCV genotype, presence of liver damage, and prior treatment history.
– Follow healthcare provider’s specific instructions regarding duration and dosing.
Side Effects, Contraindications, or Interactions:
– Common side effects include fatigue, headache, nausea, and insomnia.
– Contraindicated in patients with known hypersensitivity to ledipasvir, sofosbuvir, or any tablet components.
– Caution when used with other medications, especially certain antiretrovirals and enzyme inducers that may reduce effectiveness.
– Liver and kidney function should be monitored during treatment.
– Use under medical supervision with regular monitoring for effectiveness and side effects.
Adhere strictly to prescribed regimen for optimal treatment outcomes.
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